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Molecule Parameter List for NO_a | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| NO_a participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | CondorelliGC | 19 | Pathway |
condorelliGCmod | | This model features the observations of Condorelli P, George SC. Biophys J. (2001) 80(5):2110-9. They propose a in vivo mechanism for the binding of free NO to sGC based on in vitro data within both pulmonary and vascular smooth muscle. All the parameters used have been obtained from reported results based on experiments. One important conclusion they make is that control of sGC in vivo is most likely to be ultra-sensitive and that activation in vivo occurs at lower NO concentrations than previously reported. |
NO_a acting as a Molecule in CondorelliGC Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | NO_a | CondorelliGC
Accession No. : 19 | condorelliGCmod
Pathway No. : 89 | 0.1 | 0.0016667 | No | | |
NO_a acting as a Substrate in a reaction in CondorelliGC Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | NOdepPway | CondorelliGC
Accession No. : 19 | condorelliGCmod
Pathway No. : 89 | 1.68
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
NO_a
NO_sGCpart_act
Product
NO_sGCfull_act
| | Rates from stopped flow experiments performed at 4C from Zhao et al., 1999, PNAS,96:14753-14758. Same rates used by Condorelli P, for his simulations... |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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