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Molecule Parameter List for cAMP4.R2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

cAMP4.R2 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
cAMP_pathway	25	Network	Shared_Object_cAMP_pathway,  PKA,  AC,   Gs
This is a model of the canonical cAMP signaling pathway: Ligand->Receptor->G-protein->Cyclase->cAMP->PKA. It also includes phosphodiesterases to balance out cAMP formation.Bhalla US Methods Enzymol. 2002;345:3-23

cAMP4.R2 acting as a Molecule in  cAMP_pathway Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
cAMP4.R2	cAMP_pathway Accession No. : 25	PKA Pathway No. : 135	0	1000	No
Starts at 0.15 for the test of fig 6 in Smith et al, but we aren't using that paper any more.

cAMP4.R2 acting as a Product in a reaction in  cAMP_pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
Release-C2	cAMP_pathway Accession No. : 25	PKA Pathway No. : 135	60 (s^-1)	18 (uM^-1 s^-1)	Kd(cb) = 0.3(uM)	-	Substrate cAMP4.R2C Product PKA-active cAMP4.R2