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Molecule Parameter List for 3kCaM*_ip3_cmplx

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

3kCaM*_ip3_cmplx participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	1	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	31	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

3kCaM*_ip3_cmplx acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
3kCaM*_ip3_cmplx	NonOsc_Ca_ IP3metabolism Accession No. : 31	IP3-3K Pathway No. : 148	0	1000	No
Enzyme complex exclusively modeled as M-M kinetics do not hold. Enzyme is reversible as per free energy calculations that yield a a significant back flux.

3kCaM*_ip3_cmplx acting as a Substrate in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
3k-CaM*-off	NonOsc_Ca_ IP3metabolism Accession No. : 31	IP3-3K Pathway No. : 148	45 (s^-1)	0.4148 (uM^-1 s^-1)	Kd(cb) = 0.0092(uM)	-	Substrate 3kCaM*_ip3_ cmplx Product IP3_3K_CaM* IP4(1345)
Kf = Vmax for enzyme (Communi et al, EMBO J 16(8)) Vmax is such that enzyme activity is 9 fold above basal. Kb derived from Keq value when reaction free energy = -10 kJ/mol

3kCaM*_ip3_cmplx acting as a Product in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
3k-CaM*-on	NonOsc_Ca_ IP3metabolism Accession No. : 31	IP3-3K Pathway No. : 148	80.358 (uM^-1 s^-1)	180 (s^-1)	Kd(bf) = 2.24(uM)	-	Substrate IP3(145) IP3_3K_CaM* Product 3kCaM*_ip3_ cmplx
Rates from Km of enzyme Communi et al, EMBO J 16(8)