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Accession Type:
Network
NonOsc_Ca_
IP3metabolism
MIPP
CaMKII
CaM
PKC
IP3-3K
CaRegulation
Gq
PLCbeta
134_dephos
145_dephos
IP4-system
IHP-system
1345_dephos

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Accession information for NonOsc_Ca_IP3metabolism (Accession Number 31)

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Accession Basic Parameters

Name NonOsc_Ca_IP3metabolism
Accession Type Network
Transcriber Jyoti Mishra, NCBS
Developer Jyoti Mishra, NCBS
Entry Date (YYYY-MM-DD) 2002-04-03
Species Generic mammalian
Tissue Brain - Neuronal
Cell Compartment Cytosol
Source Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )
Methodology Quantitative match to experiments, Qualitative
Model Implementation Exact GENESIS implementation
Model Validation Approximates original data
Notes This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

Conversion formats

FormatFile
Native Format (GENESIS format)    acc31.g   
GENESIS Format (Annotated version)    Anno_acc31.g   



Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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