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Molecule Parameter List for DAG-Ca-PLA2*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
DAG-Ca-PLA2* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK-bistability
    -fig1c
    		• 35Network
    Shared_Object_MAPK-bistability-fig1c,  Sos,  PKC,  
    MAPK,  PLA2,  Ras,  
    PDGFR 
    Model for figure 1c in Bhalla US et al. Science (2002) 297(5583):1018-23.
    The demo for this figure is available here. This synaptic signaling model is without the MKP-1 feedback, so it is bistable and remains so over long periods.

    DAG-Ca-PLA2* acting as a Molecule in      MAPK-bistability-fig1c Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    DAG-Ca-PLA2*
  • MAPK-bistability
    -fig1c
    Accession No. : 35
    		• PLA2
    Pathway No. : 183    		01000No

    DAG-Ca-PLA2* acting as an Enzyme in      MAPK-bistability-fig1c Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    DAG-Ca-PLA2* /
    kenz
  • MAPK-bistability
    -fig1c
    Accession No. : 35
    		• PLA2
    Pathway No. : 183    		20604explicit E-S complexSubstrate
    APC

    Product
    AA
    Based on Leslie and Channon 1990 BBA 1045:261.

    DAG-Ca-PLA2* acting as a Product in a reaction in      MAPK-bistability-fig1c Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    DAG-Ca-PLA2-act
  • MAPK-bistability
    -fig1c
    Accession No. : 35
    		• PLA2
    Pathway No. : 183    		0.003
    (uM^-1 s^-1)    		4
    (s^-1)    		Kd(bf) = 1333.3333(uM)-Substrate
    DAG
    PLA2-Ca*

    Product
    DAG-Ca-PLA2*
    Synergistic activation of PLA2 by Ca and DAG. Based on Leslie and Channon 1990 BBA 1045:261 The Kd is rather large and may reflect the complications in measuring DAG. For this model it is not critical since DAG is held fixed.


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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