DOQCS database

NCBS Home page

Accession List

Pathway List

Authorized Users

Help

News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.

Molecule Parameter List for CyclinA

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CyclinA* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CDK2-CyclinA_ activation_ pathway	42	Pathway	CDK2-CyclinA
In this version of the CDK2/Cyclin A complex activation there is discrepancy in the first curve which plots the binding reaction of CDK2 and Cyclin A expressed in E. coli. With the published rate constants the simulation does not match the published graph (Fig.1B) in Morris MC. et al. J Biol Chem. (2002) 277(26):23847-53.

CyclinA acting as a Molecule in CDK2-CyclinA_activation_pathway Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CyclinA	CDK2-CyclinA_ activation_ pathway Accession No. : 42	CDK2-CyclinA Pathway No. : 190	0.4	999.98	No
CoInit = 0.4 uM Morris et al (2002 june 28) J Biol Chem. 277(26):23847-53 Fig.1 pp.23848

CyclinA acting as a Substrate in a reaction in CDK2-CyclinA_activation_pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
Binding	CDK2-CyclinA_ activation_ pathway Accession No. : 42	CDK2-CyclinA Pathway No. : 190	18.9999 (uM^-1 s^-1)	25 (s^-1)	Kd(bf) = 1.3158(uM)	-	Substrate Cdk2 CyclinA Product CDK2cycA
kf = 19/sec/uM and kb = 25/sec Morris et al (2002 june 28) J Biol Chem. 277(26):23847-53 Table 1 pp.23849.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.