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Molecule Parameter List for Cdk2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Cdk2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • CDK2-CyclinA_
    activation_
    pathway
    		• 42Pathway
    CDK2-CyclinA 
    In this version of the CDK2/Cyclin A complex activation there is discrepancy in the first curve which plots the binding reaction of CDK2 and Cyclin A expressed in E. coli. With the published rate constants the simulation does not match the published graph (Fig.1B) in Morris MC. et al. J Biol Chem. (2002) 277(26):23847-53.

    Cdk2 acting as a Molecule in      CDK2-CyclinA_activation_pathway Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    Cdk2
  • CDK2-CyclinA_
    activation_
    pathway
    Accession No. : 42
    		• CDK2-CyclinA
    Pathway No. : 190    		0.1999.98No
    CoInit = 0.1uM Morris et al 2002 JBC 277(26): 23847--23853 Fig.1 pp.23848

    Cdk2 acting as a Substrate in a reaction in      CDK2-CyclinA_activation_pathway Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Binding
  • CDK2-CyclinA_
    activation_
    pathway
    Accession No. : 42
    		• CDK2-CyclinA
    Pathway No. : 190    		18.9999
    (uM^-1 s^-1)    		25
    (s^-1)    		Kd(bf) = 1.3158(uM)-Substrate
    Cdk2
    CyclinA

    Product
    CDK2cycA
    kf = 19/sec/uM and kb = 25/sec Morris et al (2002 june 28) J Biol Chem. 277(26):23847-53
    Table 1 pp.23849.


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