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Molecule Parameter List for Cdk2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cdk2 participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
activation_ pathway | 42 | Pathway | CDK2-CyclinA |
| In this version of the CDK2/Cyclin A complex activation there is discrepancy in the first curve which plots the binding reaction of CDK2 and Cyclin A expressed in E. coli. With the published rate constants the simulation does not match the published graph (Fig.1B) in Morris MC. et al. J Biol Chem. (2002) 277(26):23847-53. | |||
Cdk2 acting as a Molecule in CDK2-CyclinA_activation_pathway Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| Cdk2 | activation_ pathway Accession No. : 42 | CDK2-CyclinA Pathway No. : 190 | 0.1 | 999.98 | No | |
| CoInit = 0.1uM Morris et al 2002 JBC 277(26): 23847--23853 Fig.1 pp.23848 | ||||||
Cdk2 acting as a Substrate in a reaction in CDK2-CyclinA_activation_pathway Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| Binding | activation_ pathway Accession No. : 42 | CDK2-CyclinA Pathway No. : 190 | 18.9999 (uM^-1 s^-1) | 25 (s^-1) | Kd(bf) = 1.3158(uM) | - | Substrate Cdk2 CyclinA Product CDK2cycA |
| kf = 19/sec/uM and kb = 25/sec Morris et al (2002 june 28) J Biol Chem. 277(26):23847-53 Table 1 pp.23849. | |||||||