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Molecule Parameter List for CDK2cycA*
The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.
In this version of the CDK2/Cyclin A complex activation there is discrepancy in the first curve which plots the binding reaction of CDK2 and Cyclin A expressed in E. coli. With the published rate constants the simulation does not match the published graph (Fig.1B) in Morris MC. et al. J Biol Chem. (2002) 277(26):23847-53.
The volume of this pool is scaled to 1/5.8 times the general volume in the model (1e-15 m^3) so that the range of fluorescent changes is 0.058 for complete consumption of the fluorophore (0.1 uM of Cdk2). The volume is therefore 0.1724e-15
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider.
Morris et al 2002 JBC 277(26): 23847--23853 kf and kb values not published kobs2 = 2.5 +- 0.1 /sec kf=0.813/sec and kb=0.557/sec used in simulation
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