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Molecule Parameter List for basal_fluorescence | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| basal_fluorescence participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
activation_ pathway | 42 | Pathway | CDK2-CyclinA |
| In this version of the CDK2/Cyclin A complex activation there is discrepancy in the first curve which plots the binding reaction of CDK2 and Cyclin A expressed in E. coli. With the published rate constants the simulation does not match the published graph (Fig.1B) in Morris MC. et al. J Biol Chem. (2002) 277(26):23847-53. | |||
basal_fluorescence acting as a Molecule in CDK2-CyclinA_activation_pathway Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| basal_fluorescence | activation_ pathway Accession No. : 42 | CDK2-CyclinA Pathway No. : 190 | 1.2121 | 72 | No | |
| Basal fluorescence is 1.2121 Based on data points extracted from Morris et al 2002 JBC 277(26): 23847--23853 Fig.1B inset, page 23848 | ||||||
basal_fluorescence acting as a Summed Molecule in CDK2-CyclinA_activation_pathway Network
| Accession Name | Pathway Name | Target | Input |
activation_ pathway Accession No. : 42 | CDK2-CyclinA Pathway No. : 190 | total_fluorescence | CDK2cycA CDK2cycA* fluorescence |
| The volume of this pool is scaled to 1/5.8 times the general volume in the model (1e-15 m^3) so that the range of fluorescent changes is 0.058 for complete consumption of the fluorophore (0.1 uM of Cdk2). The volume is therefore 0.1724e-15 | |||