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Molecule Parameter List for CyclinA

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CyclinA participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • CDK2-CyclinA_
    activation_
    improved
    		• 43Pathway
    CDK2_CyclinA_activation_improved 
    This version of the model for CDK2/Cyclin A complex activation (expressed in E. coli) is a good match to the data and the simulation matches the graphs Fig.1B and Fig.1B inset. The rate constants though differ from the rate constants in Morris MC. et al. J Biol Chem. (2002) 277(26):23847-53.

    CyclinA acting as a Molecule in      CDK2-CyclinA_activation_improved Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    CyclinA
  • CDK2-CyclinA_
    activation_
    improved
    Accession No. : 43
  • CDK2_CyclinA_
    activation_
    improved
    Pathway No. : 191
    		• 0.4999.98No
    CoInit = 0.4 uM Morris et al (2002 june 28) J Biol Chem. 277(26): 23847--23853
    Fig.1 pp.23848

    CyclinA acting as a Substrate in a reaction in      CDK2-CyclinA_activation_improved Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Binding
  • CDK2-CyclinA_
    activation_
    improved
    Accession No. : 43
  • CDK2_CyclinA_
    activation_
    improved
    Pathway No. : 191
    		• 33
    (uM^-1 s^-1)    		50
    (s^-1)    		Kd(bf) = 1.5152(uM)-Substrate
    Cdk2
    CyclinA

    Product
    CDK2cycA
    kf = 33/sec/uM and kb = 50/sec differs from the values in Morris et al (2002 june 28) J Biol Chem. 277(26):23847-53
    Table 1 pp.23849 Published kf = 19/sec/uM and kb = 25/sec


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