Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.

Search in:

ALL Accession Pathway Molecule Enzyme Reaction Connected to

Search for

Match

Anything Exact Word Starting With

By

Name Notes Model

Molecule Parameter List for CyclinA

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

CyclinA participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CDK2-CyclinA_ activation_ improved	43	Pathway	CDK2_CyclinA_activation_improved
This version of the model for CDK2/Cyclin A complex activation (expressed in E. coli) is a good match to the data and the simulation matches the graphs Fig.1B and Fig.1B inset. The rate constants though differ from the rate constants in Morris MC. et al. J Biol Chem. (2002) 277(26):23847-53.

CyclinA acting as a Molecule in  CDK2-CyclinA_activation_improved Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CyclinA	CDK2-CyclinA_ activation_ improved Accession No. : 43	CDK2_CyclinA_ activation_ improved Pathway No. : 191	0.4	999.98	No
CoInit = 0.4 uM Morris et al (2002 june 28) J Biol Chem. 277(26): 23847--23853 Fig.1 pp.23848

CyclinA acting as a Substrate in a reaction in  CDK2-CyclinA_activation_improved Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
Binding	CDK2-CyclinA_ activation_ improved Accession No. : 43	CDK2_CyclinA_ activation_ improved Pathway No. : 191	33 (uM^-1 s^-1)	50 (s^-1)	Kd(bf) = 1.5152(uM)	-	Substrate Cdk2 CyclinA Product CDK2cycA
kf = 33/sec/uM and kb = 50/sec differs from the values in Morris et al (2002 june 28) J Biol Chem. 277(26):23847-53 Table 1 pp.23849 Published kf = 19/sec/uM and kb = 25/sec