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Molecule Parameter List for basal_fluorescence

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
basal_fluorescence participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1100000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • CDK2-CyclinA_
    activation_
    improved
    		• 43Pathway
    CDK2_CyclinA_activation_improved 
    This version of the model for CDK2/Cyclin A complex activation (expressed in E. coli) is a good match to the data and the simulation matches the graphs Fig.1B and Fig.1B inset. The rate constants though differ from the rate constants in Morris MC. et al. J Biol Chem. (2002) 277(26):23847-53.

    basal_fluorescence acting as a Molecule in      CDK2-CyclinA_activation_improved Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    basal_fluorescence
  • CDK2-CyclinA_
    activation_
    improved
    Accession No. : 43
  • CDK2_CyclinA_
    activation_
    improved
    Pathway No. : 191
    		• 1.212172No
    Basal fluorescence is 1.2121 Based on data points extracted from Morris et al 2002 JBC 277(26): 23847--23853 Fig.1B inset, page 23848

    basal_fluorescence acting as a Summed Molecule in      CDK2-CyclinA_activation_improved Network
    Accession NamePathway NameTargetInput
  • CDK2-CyclinA_
    activation_
    improved
    Accession No. : 43
  • CDK2_CyclinA_
    activation_
    improved
    Pathway No. : 191
    		• total_fluorescenceCDK2cycA
    CDK2cycA*
  • basal_
    fluorescence
    • The volume of this pool is scaled to 1/5.8 times the general volume in the model (1e-15 m^3) so that the range of fluorescent changes is 0.058 for complete consumption of the fluorophore (0.1 uM of Cdk2). The volume is therefore 0.1724e-15


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