| Name | MAPK_Asthagiri_adapt_fb |
| Accession Type | Pathway |
| Transcriber | Pradeep Kumar S, NCBS |
| Developer | Anand R. Asthagiri and Douglas A. Lauffenburger |
| Entry Date (YYYY-MM-DD) | 2003-02-22 00:00:00 |
| Species | Chinese hamster (Cricetulus griseus); mammalian |
| Tissue | Ovary - CHO cell line |
| Cell Compartment | Surface, cytosol |
| Source | Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39. ( peer-reviewed publication ). |
| Methodology | Quantitative match to experiments, Qualitative |
| Model Implementation | Mathematically equivalent |
| Model Validation | Replicates orginal data, Approximates original data |
| Notes | This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines, particularly the role of adapter targeted negative feedback mechanism in generating complete signal adaptation. This model simulates the results as per the figure 7A of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39. |
