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Molecule Parameter List for C2 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | MAPK_Asthagiri_
enz_fb | 46 | Pathway |
MAPK_Asthagiri_enz_fb | This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines, particularly the role of enzyme targeted negative feedback mechanism in generating downstream signal adaptation. This model simulates the results as per the simulation conditions specified for figure 7B of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39.
However, there is some discrepancy with the outputs shown in Figure 7B. |
C2 acting as a Molecule in MAPK_Asthagiri_enz_fb Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | C2 | MAPK_Asthagiri_
enz_fb
Accession No. : 46 | MAPK_Asthagiri_
enz_fb
Pathway No. : 194 | 0 | 390 | No | | Dimer formed by receptor binding from Asthagiri and Lauffenburger 2001 |
C2 acting as a Substrate in a reaction in MAPK_Asthagiri_enz_fb Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | C2-phos | MAPK_Asthagiri_
enz_fb
Accession No. : 46 | MAPK_Asthagiri_
enz_fb
Pathway No. : 194 | 0.833
(s^-1) | 0.0833
(s^-1) | Keq = 0.1(uM) | 1.091sec | Substrate
C2
Product
C*
| | Kc+ is 50min-1 and Kc- is 5min-1 from Asthagiri and Lauffenburger 2001. |
C2 acting as a Product in a reaction in MAPK_Asthagiri_enz_fb Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | C-dimer | MAPK_Asthagiri_
enz_fb
Accession No. : 46 | MAPK_Asthagiri_
enz_fb
Pathway No. : 194 | 1
(uM^-1 s^-1) | 1
(s^-1) | Keq = 1(uM) | - | Substrate
C
C
Product
C2
| | Kc is 6*10^7 M-1 min-1 and Ku is 60 min-1 from Asthagiri, A.R and Lauffenburger, D.A Biotechnol. Prog. 2001, 17, 227-239. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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