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Accession information for MAPK_Asthagiri_enz_fb (Accession Number 46)

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Accession Basic Parameters

Name MAPK_Asthagiri_enz_fb
Accession Type Pathway
Transcriber Pradeep Kumar S, NCBS
Developer Anand R. Asthagiri and Douglas A. Lauffenburger
Entry Date (YYYY-MM-DD) 2003-02-22 00:00:00
Species Chinese hamster (Cricetulus griseus); mammalian
Tissue Ovary - CHO cell line
Cell Compartment Surface + cytosol
Source Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39. ( peer-reviewed publication ).
Methodology Qualitative
Model Implementation Approximate implementation
Model Validation Approximates original data
Notes This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines, particularly the role of enzyme targeted negative feedback mechanism in generating downstream signal adaptation. This model simulates the results as per the simulation conditions specified for figure 7B of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39.
However, there is some discrepancy with the outputs shown in Figure 7B.

Conversion formats

Native Format (GENESIS format)    acc46.g   
GENESIS Format (Annotated version)    Anno_acc46.g   
MATLAB format    acc46.m   
SBML format    acc46.xml   

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