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Molecule Parameter List for E2- | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| E2- participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | MAPK_Asthagiri_
enz_fb | 46 | Pathway |
MAPK_Asthagiri_enz_fb | This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines, particularly the role of enzyme targeted negative feedback mechanism in generating downstream signal adaptation. This model simulates the results as per the simulation conditions specified for figure 7B of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39.
However, there is some discrepancy with the outputs shown in Figure 7B. |
E2- acting as a Molecule in MAPK_Asthagiri_enz_fb Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | E2- | MAPK_Asthagiri_
enz_fb
Accession No. : 46 | MAPK_Asthagiri_
enz_fb
Pathway No. : 194 | 0 | 390 | No | | Nonfunctional second enzyme of enzyme cascade E2- from Asthagiri and Lauffnburger, 2001 |
E2- acting as a Product of an Enzyme in MAPK_Asthagiri_enz_fb Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | E4* /
E4*_enz_
targeted_fb
| MAPK_Asthagiri_
enz_fb
Accession No. : 46 | MAPK_Asthagiri_
enz_fb
Pathway No. : 194 | 0.0600001 | 0.1 | 5 | explicit E-S complex | Substrate
E2*
Product
E2-
| | Implementation of enzyme feedback induces adaptation of e2* and signals downstream of the target signal, but not those signals upstream of the target e0* and e1*. k5+ =6*10^8 M-1 min-1, k5- =30 min-1, kcat,5 =6 min-1 from Asthagiri and Lauffenburger 2001. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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