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Molecule Parameter List for PKA-inhibitor | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PKA-inhibitor participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| PKA_2003 | 47 | Network | Shared_Object_PKA_2003, PKA, AC, Gs |
| This model consists of receptor-ligand interaction, G-protein activation, Adenylyl cyclase mediated formation of cAMP and activation of PKA in the neuron. Demonstration programs using this model described in Bhalla US. (2004) Biophys J. 87(2):733-44 to generate a dose-response curve using stochastic calculations are available here. | |||
PKA-inhibitor acting as a Molecule in PKA_2003 Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| PKA-inhibitor | PKA_2003 Accession No. : 47 | PKA Pathway No. : 196 | 0.25 | 1000 | No | |
| About 25% of PKA C subunit is dissociated in resting cells without having any noticable activity. Doskeland SO and Ogreid D (1981) Int J Biochem 13(1):1-19 suggest that this is because there is a corresponding amount of inhibitor protein. | ||||||
PKA-inhibitor acting as a Substrate in a reaction in PKA_2003 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| inhib-PKA | PKA_2003 Accession No. : 47 | PKA Pathway No. : 196 | 60 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate PKA-active PKA-inhibitor Product inhibited-PKA |
| This has to be set to zero for matching the expts in vitro. In vivo we need to consider the inhibition though. | |||||||