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Molecule Parameter List for GDP.Ga | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | PKA_2003 | 47 | Network |
Shared_Object_PKA_2003, PKA, AC,
Gs | | This model consists of receptor-ligand interaction, G-protein activation, Adenylyl cyclase mediated formation of cAMP and activation of PKA in the neuron. Demonstration programs using this model described in Bhalla US. (2004) Biophys J. 87(2):733-44 to generate a dose-response curve using stochastic calculations are available here. |
GDP.Ga acting as a Molecule in PKA_2003 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | GDP.Ga | PKA_2003
Accession No. : 47 | Gs
Pathway No. : 198 | 0 | 1000 | No | | The inactive GDP-bound form of Gs alpha. |
GDP.Ga acting as a Substrate in a reaction in PKA_2003 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | Trimerize-Gs | PKA_2003
Accession No. : 47 | Gs
Pathway No. : 198 | 6
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
GDP.Ga
Gbg
Product
GDP.Gabc
| | Negligible back-reaction. |
GDP.Ga acting as a Product in a reaction in PKA_2003 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | GTPase | PKA_2003
Accession No. : 47 | Gs
Pathway No. : 198 | 0.0667
(s^-1) | 0
(s^-1) | - | - | Substrate
GTP.Ga
Product
GDP.Ga
| | From Brandt and Ross JBC 261(4):1656-1664, rate is 4/min and is agonist independent. I treat this as irreversible. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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