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Name Notes Model

Molecule Parameter List for Gbg

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

Gbg participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	1	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
PKA_2003	47	Network	Shared_Object_PKA_2003,  PKA,  AC,   Gs
This model consists of receptor-ligand interaction, G-protein activation, Adenylyl cyclase mediated formation of cAMP and activation of PKA in the neuron. Demonstration programs using this model described in Bhalla US. (2004) Biophys J. 87(2):733-44 to generate a dose-response curve using stochastic calculations are available here.

Gbg acting as a Molecule in  PKA_2003 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Gbg	PKA_2003 Accession No. : 47	Gs Pathway No. : 198	0	1000	No
The Gbetagamma dimer.

Gbg acting as a Substrate in a reaction in  PKA_2003 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
Trimerize-Gs	PKA_2003 Accession No. : 47	Gs Pathway No. : 198	6 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GDP.Ga Gbg Product GDP.Gabc
Negligible back-reaction.

Gbg acting as a Product in a reaction in  PKA_2003 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
Activate-Gs	PKA_2003 Accession No. : 47	Gs Pathway No. : 198	0.025 (s^-1)	0 (uM^-2 s^-1)	-	-	Substrate L.R.GDP.Gabc Product GTP.Ga Gbg L.R
This step combines several stages in GTP.Galpha release. From Berstein et al activation is at .35 - 0.7/min From Fay et al Biochem 30 5066-5075 1991 kf = .01/sec. From Brandt and Ross JBC 261(4):1656-1664 (1986) and Ransan et al Biochem J 283(2):519-524 (1992) rates around 2.5/min to 1.5/min are better.