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Molecule Parameter List for neurogranin-CaM | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| neurogranin-CaM participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 1 | 0 | 0 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| CaMKII_2003 | 49 | Network | Shared_Object_CaMKII_2003, CaMKII, CaM, PP1, PP2B |
| Model of regulation of CaMKII by Calcium, including parallel excitatory input from CaM and inhibitory input from PP1 as regulated by Calcineurin and PKA. Cell type: neuronal. Bhalla US. Biophys J. 2004 Aug;87(2):733-44. | |||
neurogranin-CaM acting as a Molecule in CaMKII_2003 Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| neurogranin-CaM | CaMKII_2003 Accession No. : 49 | CaM Pathway No. : 203 | 0 | 1000 | No | |
neurogranin-CaM acting as a Substrate for an Enzyme in CaMKII_2003 Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| PKC-active / M | CaMKII_2003 Accession No. : 49 | CaMKII_2003 Pathway No. : 201 | 28.5948 | 0.35 | 4 | explicit E-S complex | Substrate neurogranin-CaM Product CaM neurogranin* |
| Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993 | |||||||
neurogranin-CaM acting as a Product in a reaction in CaMKII_2003 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
-CaM | CaMKII_2003 Accession No. : 49 | CaM Pathway No. : 203 | 0.3 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 3.3333(uM) | - | Substrate CaM neurogranin Product neurogranin-CaM |
| Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987 | |||||||