 |  EGFR_Signaling_
pathway |
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Accession information for EGFR_Signaling_pathway (Accession Number 52)
Reaction Scheme
Accession Basic Parameters
| Name | EGFR_Signaling_pathway |
| Accession Type | Pathway |
| Transcriber | Pradeep Kumar S, NCBS |
| Developer | Kholodenko et al |
| Entry Date (YYYY-MM-DD) | 2003-05-17 00:00:00 |
| Species | Harlan Sprague Dawley rat; mammalian |
| Tissue | Hepatocytes |
| Cell Compartment | Cell membrane + cytosol |
| Source | Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999. ( peer-reviewed publication ) |
| Methodology | Qualitative |
| Model Implementation | Mathematically equivalent |
| Model Validation | Approximates original data |
| Notes | This model is based on the model and parameters published in paper: Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999.
Note: There are a few small ambiguities in the paper about initial conditions employed for obtaining the results. Thanks to Dr. Kholodenko for clarifying those ambiguities and providing the values used in the simulations:[G-S]=33.04579, [Grb]=51.95431, [SOS]=0.95421. |
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| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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