Enter a Search String |
| Special character and space not allowed in the query term. Search string should be at least 2 characters long. |
Molecule Parameter List for CaMK-thr305 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CaMK-thr305 participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 1 | 0 | 1 | 1 | 0 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
model3 | 62 | Network | Shared_Object_CaMKII_noPKA_model3, CaMKII, CaM, PP1, PP2B, PP1_PSD |
| This is the model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 does not include the full PKA regulatory pathway, and instead has a predefined initial amount of active PKA. | |||
CaMK-thr305 acting as a Molecule in CaMKII_noPKA_model3 Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| CaMK-thr305 | model3 Accession No. : 62 | CaMKII Pathway No. : 258 | 0 | 0.09 | No | |
| This forms due to basal autophosphorylation, but I think it has to be considered as a pathway even if some CaM is floating around. In either case it will tend to block further binding of CaM, and will not display any enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992 | ||||||
CaMK-thr305 acting as a Summed Molecule in CaMKII_noPKA_model3 Network
| Accession Name | Pathway Name | Target | Input |
model3 Accession No. : 62 | CaMKII_noPKA_ model3 Pathway No. : 257 | tot_CaMKII_cyt | CaMKII-CaM aM CaMKII-thr286 CaMKII*** CaMK-thr305 CaMKII cyt |
CaMK-thr305 acting as a Substrate for an Enzyme in CaMKII_noPKA_model3 Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| PP1-active / Deph-thr305a | model3 Accession No. : 62 | CaMKII_noPKA_ model3 Pathway No. : 257 | 5.09905 | 2.5 | 4 | explicit E-S complex | Substrate CaMK-thr305 Product CaMKII |
CaMK-thr305 acting as a Product of an Enzyme in CaMKII_noPKA_model3 Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| PP1-active / Deph-thr286c | model3 Accession No. : 62 | CaMKII_noPKA_ model3 Pathway No. : 257 | 5.09905 | 2.5 | 4 | explicit E-S complex | Substrate CaMKII*** Product CaMK-thr305 |
CaMK-thr305 acting as a Product in a reaction in CaMKII_noPKA_model3 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| back_2 | model3 Accession No. : 62 | CaMKII_noPKA_ model3 Pathway No. : 257 | 0.3 (s^-1) | 0 (#^-1 s^-1) | Not applicable** | - | Substrate D Product CaMK-thr305 NMDAR |
| Same as for back_1 | |||||||