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Molecule Parameter List for CaMKII-thr286

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMKII-thr286 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1203110

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • CaMKII_noPKA_
    model3
  • 62Network
    Shared_Object_CaMKII_noPKA_model3 CaMKII CaM 
    PP1 PP2B PP1_PSD 
    This is the model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 does not include the full PKA regulatory pathway, and instead has a predefined initial amount of active PKA.

    CaMKII-thr286 acting as a Molecule in  
    CaMKII_noPKA_model3 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    CaMKII-thr286
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • CaMKII
    Pathway No. : 258
    00.09No
    I am not sure if we need to endow this one with a lot of enzs. It is likely to be a short-lived intermediate, since it will be phosphorylated further as soon as the CAM falls off.

    CaMKII-thr286 acting as a Summed Molecule in  
    CaMKII_noPKA_model3 Network
     Accession NanePathway NameTargetInput
    1
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • CaMKII
    Pathway No. : 258
    tot_autonomous_CaMKIICaMKII-thr286
    CaMKII***
  • basal_CaMKII_
    cyt

  • 2
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • Shared_Object_
    CaMKII_noPKA_
    model3

    Pathway No. : 257
  • tot_CaMKII_cytCaMKII-CaM
  • CaMKII-thr286*-C
    aM

    CaMKII-thr286
    CaMKII***
    CaMK-thr305
    CaMKII
  • basal_CaMKII_
    cyt


  • CaMKII-thr286 acting as a Substrate for an Enzyme in  
    CaMKII_noPKA_model3 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PP1-active  /
    Deph-thr286b
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • Shared_Object_
    CaMKII_noPKA_
    model3

    Pathway No. : 257
  • 5.099052.54explicit E-S complexSubstrate
    CaMKII-thr286

    Product
    CaMKII
    2tot_CaM_CaMKII  /
    CaM_act_305
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • CaMKII
    Pathway No. : 258
    226.99864explicit E-S complexSubstrate
    CaMKII-thr286

    Product
    CaMKII***
        Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
    3
  • tot_autonomous_
    CaMKII
      /
    auton_305
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • CaMKII
    Pathway No. : 258
    35064explicit E-S complexSubstrate
    CaMKII-thr286

    Product
    CaMKII***
        See Hanson and Schulman again, for afterburst rates of phosph.

    CaMKII-thr286 acting as a Product of an Enzyme in  
    CaMKII_noPKA_model3 Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1-active  /
    Deph-thr305
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • Shared_Object_
    CaMKII_noPKA_
    model3

    Pathway No. : 257
  • 5.099052.54explicit E-S complexSubstrate
    CaMKII***

    Product
    CaMKII-thr286

    CaMKII-thr286 acting as a Substrate in a reaction in  
    CaMKII_noPKA_model3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • CaMK-thr286-bind
    -CaM
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • CaMKII
    Pathway No. : 258
    1000.19
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 0.0001(uM)-Substrate
    CaM-Ca4
    CaMKII-thr286

    Product
  • CaMKII-thr286*-C
    aM

  • Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3



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