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Molecule Parameter List for CaMK-thr305

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMK-thr305 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1101101

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • CaMKII_noPKA_
    model3
  • 62Network
    Shared_Object_CaMKII_noPKA_model3 CaMKII CaM 
    PP1 PP2B PP1_PSD 
    This is the model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 does not include the full PKA regulatory pathway, and instead has a predefined initial amount of active PKA.

    CaMK-thr305 acting as a Molecule in  
    CaMKII_noPKA_model3 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    CaMK-thr305
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • CaMKII
    Pathway No. : 258
    00.09No
    This forms due to basal autophosphorylation, but I think it has to be considered as a pathway even if some CaM is floating around. In either case it will tend to block further binding of CaM, and will not display any enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992

    CaMK-thr305 acting as a Summed Molecule in  
    CaMKII_noPKA_model3 Network
    Accession NamePathway NameTargetInput
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • Shared_Object_
    CaMKII_noPKA_
    model3

    Pathway No. : 257
  • tot_CaMKII_cytCaMKII-CaM
  • CaMKII-thr286*-C
    aM

    CaMKII-thr286
    CaMKII***
    CaMK-thr305
    CaMKII
  • basal_CaMKII_
    cyt


  • CaMK-thr305 acting as a Substrate for an Enzyme in  
    CaMKII_noPKA_model3 Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1-active  /
    Deph-thr305a
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • Shared_Object_
    CaMKII_noPKA_
    model3

    Pathway No. : 257
  • 5.099052.54explicit E-S complexSubstrate
    CaMK-thr305

    Product
    CaMKII

    CaMK-thr305 acting as a Product of an Enzyme in  
    CaMKII_noPKA_model3 Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1-active  /
    Deph-thr286c
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • Shared_Object_
    CaMKII_noPKA_
    model3

    Pathway No. : 257
  • 5.099052.54explicit E-S complexSubstrate
    CaMKII***

    Product
    CaMK-thr305

    CaMK-thr305 acting as a Product in a reaction in  
    CaMKII_noPKA_model3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    back_2
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • Shared_Object_
    CaMKII_noPKA_
    model3

    Pathway No. : 257
  • 0.3
    (s^-1)
    0
    (#^-1 s^-1)
    Not applicable**-Substrate
  • CaMKII-thr305-PS
    D


    Product
    CaMK-thr305
    NMDAR
  • Same as for back_1
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration



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