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Molecule Parameter List for CaMKII-CaM-PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

CaMKII-CaM-PSD participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	2	0	2	1	1	2

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CaMKII_noPKA_ model3	62	Network	Shared_Object_CaMKII_noPKA_model3,  CaMKII,  CaM,   PP1,  PP2B,  PP1_PSD
This is the model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 does not include the full PKA regulatory pathway, and instead has a predefined initial amount of active PKA.

CaMKII-CaM-PSD acting as a Molecule in  CaMKII_noPKA_model3 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMKII-CaM-PSD	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	0	0.01	No

CaMKII-CaM-PSD acting as a Summed Molecule in  CaMKII_noPKA_model3 Network

	Accession Nane	Pathway Name	Target	Input
1	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	actCaMKII-PSD	CaMKII-thr286-Ca M-PSD CaMKII-CaM-PSD tot-auto-PSD
2	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	tot-CaM-CaMKII-PSD	CaMKII-thr286-Ca M-PSD CaMKII-CaM-PSD

CaMKII-CaM-PSD acting as a Substrate for an Enzyme in  CaMKII_noPKA_model3 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot-auto-PSD  / auton-286-PSD	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	500.002	0.5	4	explicit E-S complex	Substrate CaMKII-CaM-PSD Product CaMKII-thr286-Ca M-PSD
2	tot-CaM-CaMKII-P SD  / CaM-act-286-PSD	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	319.996	0.5	4	explicit E-S complex	Substrate CaMKII-CaM-PSD Product CaMKII-thr286-Ca M-PSD

CaMKII-CaM-PSD acting as a Product of an Enzyme in  CaMKII_noPKA_model3 Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PP1-active_PSD  / Deph-thr286	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII-thr286-Ca M-PSD Product CaMKII-CaM-PSD

CaMKII-CaM-PSD acting as a Substrate in a reaction in  CaMKII_noPKA_model3 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
CaMKII-diss-CaM	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	5 (s^-1)	0 (uM^-1 s^-1)	-	-	Substrate CaMKII-CaM-PSD Product CaM-Ca4-PSD CaMKII-PSD

CaMKII-CaM-PSD acting as a Product in a reaction in  CaMKII_noPKA_model3 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	CaMKII-bind-CaM- PSD	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	49.9998 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate CaM-Ca4-PSD CaMKII-PSD Product CaMKII-CaM-PSD
2	transloc_1	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	0 (#^-1 s^-1)	0 (s^-1)	Not applicable**	-	Substrate CaMKII-CaM NMDAR Product CaMKII-CaM-PSD
	Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration