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Molecule Parameter List for CaMKII-thr286-CaM-PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CaMKII-thr286-CaM-PSD* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	3	0	1	2	0	2

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CaMKII_noPKA_ model3	62	Network	Shared_Object_CaMKII_noPKA_model3, CaMKII, CaM, PP1, PP2B, PP1_PSD
This is the model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 does not include the full PKA regulatory pathway, and instead has a predefined initial amount of active PKA.

CaMKII-thr286-CaM-PSD acting as a Molecule in CaMKII_noPKA_model3 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMKII-thr286-CaM-PSD	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	0	0.01	No

CaMKII-thr286-CaM-PSD acting as a Summed Molecule in CaMKII_noPKA_model3 Network

	Accession Nane	Pathway Name	Target	Input
1	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	286P-PSD	CaMKII-thr286-Ca M-PSD CaMKII-thr286-PS D
2	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	actCaMKII-PSD	CaMKII-thr286-Ca M-PSD CaMKII-CaM-PSD tot-auto-PSD
3	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	tot-CaM-CaMKII-PSD	CaMKII-thr286-Ca M-PSD CaMKII-CaM-PSD

CaMKII-thr286-CaM-PSD acting as a Substrate for an Enzyme in CaMKII_noPKA_model3 Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PP1-active_PSD / Deph-thr286	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII-thr286-Ca M-PSD Product CaMKII-CaM-PSD

CaMKII-thr286-CaM-PSD acting as a Product of an Enzyme in CaMKII_noPKA_model3 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot-auto-PSD / auton-286-PSD	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	500.002	0.5	4	explicit E-S complex	Substrate CaMKII-CaM-PSD Product CaMKII-thr286-Ca M-PSD
2	tot-CaM-CaMKII-P SD / CaM-act-286-PSD	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	319.996	0.5	4	explicit E-S complex	Substrate CaMKII-CaM-PSD Product CaMKII-thr286-Ca M-PSD

CaMKII-thr286-CaM-PSD acting as a Product in a reaction in CaMKII_noPKA_model3 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	transloc_2	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	0 (#^-1 s^-1)	0 (s^-1)	Not applicable**	-	Substrate CaMKII-thr286-C aM NMDAR Product* CaMKII-thr286-Ca M-PSD
	Same as for transloc_1
2	CaMKII-thr286-bi nd-CaM-PSD	CaMKII_noPKA_ model3 Accession No. : 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. : 257	1000.02 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0001(uM)	-	Substrate CaM-Ca4-PSD CaMKII-thr286-PS D Product CaMKII-thr286-Ca M-PSD
	Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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