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Molecule Parameter List for CaMKII-CaM-PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMKII-CaM-PSD participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1202112

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • CaMKII_noPKA_
    model3
  • 62Network
    Shared_Object_CaMKII_noPKA_model3 CaMKII CaM 
    PP1 PP2B PP1_PSD 
    This is the model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 does not include the full PKA regulatory pathway, and instead has a predefined initial amount of active PKA.

    CaMKII-CaM-PSD acting as a Molecule in  
    CaMKII_noPKA_model3 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    CaMKII-CaM-PSD
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • Shared_Object_
    CaMKII_noPKA_
    model3

    Pathway No. : 257
  • 00.01No

    CaMKII-CaM-PSD acting as a Summed Molecule in  
    CaMKII_noPKA_model3 Network
     Accession NanePathway NameTargetInput
    1
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • Shared_Object_
    CaMKII_noPKA_
    model3

    Pathway No. : 257
  • actCaMKII-PSD
  • CaMKII-thr286-Ca
    M-PSD

    CaMKII-CaM-PSD
    tot-auto-PSD
  • 2
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • Shared_Object_
    CaMKII_noPKA_
    model3

    Pathway No. : 257
  • tot-CaM-CaMKII-PSD
  • CaMKII-thr286-Ca
    M-PSD

    CaMKII-CaM-PSD

  • CaMKII-CaM-PSD acting as a Substrate for an Enzyme in  
    CaMKII_noPKA_model3 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1tot-auto-PSD  /
    auton-286-PSD
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • Shared_Object_
    CaMKII_noPKA_
    model3

    Pathway No. : 257
  • 500.0020.54explicit E-S complexSubstrate
    CaMKII-CaM-PSD

    Product
  • CaMKII-thr286-Ca
    M-PSD

  • 2
  • tot-CaM-CaMKII-P
    SD
      /
    CaM-act-286-PSD
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • Shared_Object_
    CaMKII_noPKA_
    model3

    Pathway No. : 257
  • 319.9960.54explicit E-S complexSubstrate
    CaMKII-CaM-PSD

    Product
  • CaMKII-thr286-Ca
    M-PSD


  • CaMKII-CaM-PSD acting as a Product of an Enzyme in  
    CaMKII_noPKA_model3 Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1-active_PSD  /
    Deph-thr286
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • Shared_Object_
    CaMKII_noPKA_
    model3

    Pathway No. : 257
  • 2.000010.24explicit E-S complexSubstrate
  • CaMKII-thr286-Ca
    M-PSD


    Product
    CaMKII-CaM-PSD

  • CaMKII-CaM-PSD acting as a Substrate in a reaction in  
    CaMKII_noPKA_model3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    CaMKII-diss-CaM
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • Shared_Object_
    CaMKII_noPKA_
    model3

    Pathway No. : 257
  • 5
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    CaMKII-CaM-PSD

    Product
    CaM-Ca4-PSD
    CaMKII-PSD

    CaMKII-CaM-PSD acting as a Product in a reaction in  
    CaMKII_noPKA_model3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1
  • CaMKII-bind-CaM-
    PSD
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • Shared_Object_
    CaMKII_noPKA_
    model3

    Pathway No. : 257
  • 49.9998
    (uM^-1 s^-1)
    0
    (s^-1)
    --Substrate
    CaM-Ca4-PSD
    CaMKII-PSD

    Product
    CaMKII-CaM-PSD
    2transloc_1
  • CaMKII_noPKA_
    model3

    Accession No. : 62
  • Shared_Object_
    CaMKII_noPKA_
    model3

    Pathway No. : 257
  • 0
    (#^-1 s^-1)
    0
    (s^-1)
    Not applicable**-Substrate
    CaMKII-CaM
    NMDAR

    Product
    CaMKII-CaM-PSD
      Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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