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Molecule Parameter List for IFNRJ2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IFNRJ2 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	1	5

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Jak-Stat_ Pathway	66	Pathway	Jak-Stat_Pathway
This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6 This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. Note: There are a few ambiguities in the paper like initial concentration of IFN and some reactions were missing in the paper that were employed for obtaining the results. The graphs are almost similar to the graphs as shown in the paper but still some ambiguities regarding the concentration are there. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations.

IFNRJ2 acting as a Molecule in  Jak-Stat_Pathway Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IFNRJ2	Jak-Stat_ Pathway Accession No. : 66	Jak-Stat_ Pathway Pathway No. : 293	0	0.0016667	No
Dimer of IFN gamma liganding to the IFN gamma receptor that has JAK bound to its intracellular domain Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196

IFNRJ2 acting as a Substrate in a reaction in  Jak-Stat_Pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
IFNRJ_ activation	Jak-Stat_ Pathway Accession No. : 66	Jak-Stat_ Pathway Pathway No. : 293	0.005 (s^-1)	0 (s^-1)	-	-	Substrate IFNRJ2 Product IFNRJ2*
Dimerisation of the RJ complex leads to the phosphorylation of several tyrosine residues by JAK Kf = 0.005*10e+06 /M/sec = 0.005/uM/sec Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196

IFNRJ2 acting as a Product in a reaction in  Jak-Stat_Pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	IFNRJ_ dimerisation	Jak-Stat_ Pathway Accession No. : 66	Jak-Stat_ Pathway Pathway No. : 293	40 (uM^-1 s^-1)	0.2 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate IFNRJ IFNRJ_ Product IFNRJ2
	Dimerisation of the RJ complex Kf = 40*10e+06 /M/sec = 40/uM/sec Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
2	dephospo_ IFNRJ2*	Jak-Stat_ Pathway Accession No. : 66	Jak-Stat_ Pathway Pathway No. : 293	0.003 (s^-1)	0 (uM^-2 s^-1)	-	-	Substrate IFNRJ2*-STAT1c-S HP2 Product IFNRJ2 SHP-2 STAT1c
3	Disso_ SOCS1-IFNRJ2*-SH P2	Jak-Stat_ Pathway Accession No. : 66	Jak-Stat_ Pathway Pathway No. : 293	0.003 (s^-1)	0 (uM^-2 s^-1)	-	-	Substrate SOCS1-IFNRJ2*-SH P2 Product IFNRJ2 SHP-2 SOCS1
	Dissociation reaction of SOCS1-IFNRJ2*-SHP2. kf = 0.003/sec kb = 0/sec/uM^2 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
4	IFNRJ2*_ dephospo	Jak-Stat_ Pathway Accession No. : 66	Jak-Stat_ Pathway Pathway No. : 293	0.003 (s^-1)	0 (uM^-3 s^-1)	-	-	Substrate SOCS1-IFNRJ2*-ST AT1c-SHP-2 Product IFNRJ2 SHP-2 SOCS1 STAT1c
	SHP-2 dephosphorylates JAK-IFNR dimer complexed with SOCS1 and STAT1c Kf = 0.003 /sec Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
5	IFNRJ2*_dephosp	Jak-Stat_ Pathway Accession No. : 66	Jak-Stat_ Pathway Pathway No. : 293	0.003 (s^-1)	0 (uM^-1 s^-1)	-	-	Substrate IFNRJ2*-SHP-2 Product IFNRJ2 SHP-2
	SHP-2 dephosphorylates JAK-IFNR dimer Kf = 0.003 /sec Kb = 0 /sec/uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196