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Accession Type:
Pathway
Jak-Stat_
Pathway
Jak-Stat_
Pathway

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Accession information for Jak-Stat_Pathway (Accession Number 66)

Reaction Scheme

Accession Basic Parameters

Name Jak-Stat_Pathway
Accession Type Pathway
Transcriber Sharat J. Vayttaden and Prasoon Agarwal, NCBS
Developer Yamada S, Shiono S, Joo A, Yoshimura A
Entry Date (YYYY-MM-DD) 2006-02-13
Species mouse
Tissue Liver
Cell Compartment Cytosol, Nucleus
Source Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6. ( Peer-reviewed publication )
Methodology Quantitative match to experiments
Model Implementation Exact GENESIS implementation
Model Validation Replicates original data
Notes This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6
This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway.
Note: There are a few ambiguities in the paper like initial concentration of IFN and some reactions were missing in the paper that were employed for obtaining the results. The graphs are almost similar to the graphs as shown in the paper but still some ambiguities regarding the concentration are there. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations.

Conversion formats

FormatFile
Native Format (GENESIS format)    acc66.g   
MATLAB format    acc66.m   
SBML format    acc66.xml   



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