NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Molecule Parameter List for dup_STAT1n*-STAT1n*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
dup_STAT1n*-STAT1n* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1102000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Jak-Stat_
    Pathway
    		• 66Pathway
    Jak-Stat_Pathway 
    This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6
    This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway.
    Note: There are a few ambiguities in the paper like initial concentration of IFN and some reactions were missing in the paper that were employed for obtaining the results. The graphs are almost similar to the graphs as shown in the paper but still some ambiguities regarding the concentration are there. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations.

    dup_STAT1n*-STAT1n* acting as a Molecule in      Jak-Stat_Pathway Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    dup_STAT1n*-STAT1n*
  • Jak-Stat_
    Pathway
    Accession No. : 66
  • Jak-Stat_
    Pathway
    Pathway No. : 293
    		• 00.0016667No
    Duplicate of the STAT1c dimer Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196

    dup_STAT1n*-STAT1n* acting as a Summed Molecule in      Jak-Stat_Pathway Network
    Accession NamePathway NameTargetInput
  • Jak-Stat_
    Pathway
    Accession No. : 66
  • Jak-Stat_
    Pathway
    Pathway No. : 293
    		• dup_STAT1n*-STAT1n*STAT1n*-STAT1n*
    Duplicate of the STAT1c dimer Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196

    dup_STAT1n*-STAT1n* acting as a Substrate for an Enzyme in      Jak-Stat_Pathway Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1
  • Transcription_
    complex      /
    DNA
  • Jak-Stat_
    Pathway
    Accession No. : 66
  • Jak-Stat_
    Pathway
    Pathway No. : 293
    		• 0.40.014Classical Michaelis-Menten
    V = Etot.S.Kcat/Km+S    		Substrate
  • dup_
    STAT1n*-STAT1n*

    Product
    mRNASn
    •     Km = 400nM = 0.4uM Vmax = 0.01 nM/sec. Assume [enz] = 1 nM, then kcat = 0.01/sec. Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    2
  • Transcription_
    comp2      /
    DNA
  • Jak-Stat_
    Pathway
    Accession No. : 66
  • Jak-Stat_
    Pathway
    Pathway No. : 293
    		• 0.40.014Classical Michaelis-Menten
    V = Etot.S.Kcat/Km+S    		Substrate
  • dup_
    STAT1n*-STAT1n*

    Product
    mRNAVn
    •     Translation of mRNAVn Km = 400nM = 0.4uM kcat = 0.01/sec Appendix, Satoshi Yamada 2003 FEBS Letters 534:190-196.


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.