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Molecule Parameter List for dup_STAT1n*-STAT1n*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

dup_STAT1n*-STAT1n* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	2	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Jak-Stat_ Pathway	66	Pathway	Jak-Stat_Pathway
This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6 This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. Note: There are a few ambiguities in the paper like initial concentration of IFN and some reactions were missing in the paper that were employed for obtaining the results. The graphs are almost similar to the graphs as shown in the paper but still some ambiguities regarding the concentration are there. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations.

dup_STAT1n*-STAT1n* acting as a Molecule in  Jak-Stat_Pathway Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
dup_STAT1n*-STAT1n*	Jak-Stat_ Pathway Accession No. : 66	Jak-Stat_ Pathway Pathway No. : 293	0	0.0016667	No
Duplicate of the STAT1c dimer Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196

dup_STAT1n*-STAT1n* acting as a Summed Molecule in  Jak-Stat_Pathway Network

Accession Name	Pathway Name	Target	Input
Jak-Stat_ Pathway Accession No. : 66	Jak-Stat_ Pathway Pathway No. : 293	dup_STAT1n*-STAT1n*	STAT1n*-STAT1n*
Duplicate of the STAT1c dimer Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196

dup_STAT1n*-STAT1n* acting as a Substrate for an Enzyme in  Jak-Stat_Pathway Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	Transcription_ complex  / DNA	Jak-Stat_ Pathway Accession No. : 66	Jak-Stat_ Pathway Pathway No. : 293	0.4	0.01	4	Classical Michaelis-Menten V = Etot.S.Kcat/Km+S	Substrate dup_ STAT1n*-STAT1n* Product mRNASn
	Km = 400nM = 0.4uM Vmax = 0.01 nM/sec. Assume [enz] = 1 nM, then kcat = 0.01/sec. Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
2	Transcription_ comp2  / DNA	Jak-Stat_ Pathway Accession No. : 66	Jak-Stat_ Pathway Pathway No. : 293	0.4	0.01	4	Classical Michaelis-Menten V = Etot.S.Kcat/Km+S	Substrate dup_ STAT1n*-STAT1n* Product mRNAVn
	Translation of mRNAVn Km = 400nM = 0.4uM kcat = 0.01/sec Appendix, Satoshi Yamada 2003 FEBS Letters 534:190-196.