| Name | SOCS1_knockout |
| Accession Type | Pathway |
| Transcriber | Prasoon Agarwal and Sharat J. Vayttaden, NCBS |
| Developer | Yamada S, Shiono S, Joo A, Yoshimura A |
| Entry Date (YYYY-MM-DD) | 2006-02-13 00:00:00 |
| Species | mouse |
| Tissue | Liver |
| Cell Compartment | Nucleus , cytoplasm |
| Source | Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6. ( Peer-reviewed publication ) |
| Methodology | Quantitative match to experiments |
| Model Implementation | Exact GENESIS implementation |
| Model Validation | Approximates original data |
| Notes | This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6
This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. This is the knockout version of Jak-Stat pathway in this model the SOCS1 has been knocked out i.e it formation is not shown.
The graphs are almost similar to the graphs as shown in the paper but STAT1n graph has some ambiguities. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations. |
