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Molecule Parameter List for RanBP1.RanGTP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*RanBP1.RanGTP* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
RanGTPase	70	Network	Shared_Object_RanGTPase, Nucleus, Cytoplasm
This model represents a concentration gradient of RanGTP across the nuclear envelope. This gradient is generated by distribution of regulators of RanGTPase. We have taken a log linear plot of graphs generated by GENESIS and compared with the experimental graphs.

RanBP1.RanGTP acting as a Molecule in RanGTPase Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
RanBP1.RanGTP	RanGTPase Accession No. : 70	Cytoplasm Pathway No. : 306	0	18000	No
RanBP1.RanGTP Cytoplasmic volume = 1.8 pL = 1.8e-15 m^3 Gorlich D et al (2003) EMBO J 22(5):1088-1100

RanBP1.RanGTP acting as a Substrate for an Enzyme in RanGTPase Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
RanGAP / RanGAP	RanGTPase Accession No. : 70	Cytoplasm Pathway No. : 306	0.1	10.8	4	explicit E-S complex	Substrate RanBP1.RanGTP Product GDP.Ran-cytoplas mic
RanGAP reaction on RanGTP-RanBP1 complex kcat = 10.8 /sec Km = 0.1 uM at 25^oC Table 1. Gorlich D et al (2003) EMBO J 22(5):1088-1100

RanBP1.RanGTP acting as a Product in a reaction in RanGTPase Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
RanGTP_binding	RanGTPase Accession No. : 70	Cytoplasm Pathway No. : 306	18.0004 (uM^-1 s^-1)	0.0004 (s^-1)	Kd(bf) = 0(uM)	-	Substrate GTP.Ran-cytoplas mic RanBP1 Product RanBP1.RanGTP

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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