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Molecule Parameter List for RanGAP | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| RanGAP participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 2 | 0 | 0 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | RanGTPase | 70 | Network |
Shared_Object_RanGTPase, Nucleus, Cytoplasm | | This model represents a concentration gradient of RanGTP across the nuclear envelope. This gradient is generated by distribution of regulators of RanGTPase. We have taken a log linear plot of graphs generated by GENESIS and compared with the experimental graphs. |
RanGAP acting as a Molecule in RanGTPase Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | RanGAP | RanGTPase
Accession No. : 70 | Cytoplasm
Pathway No. : 306 | 0.7 | 18000 | No | | RanGAP: RanGAP in the cytoplasm Ran has very low intrinsic GTPase activity and is stimulated by the Ran GTPase activator RanGAP. This has an antagonistic regulator to RCC1, converting Ran into its GDP bound OFF form. F. Ralf Bischoff et al (1994) PNAS, USA 91:2587-2591 Cytoplasmic volume = 1.8 pL = 1.8e-15 m^3 Total cytoplasmic concentration of RanGAP = 0.7 uM Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100 |
RanGAP acting as an Enzyme in RanGTPase Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | RanGAP /
RanGAP
| RanGTPase
Accession No. : 70 | Cytoplasm
Pathway No. : 306 | 0.1 | 10.8 | 4 | explicit E-S complex | Substrate
RanBP1.RanGTP
Product
GDP.Ran-cytoplas
mic
| | | RanGAP reaction on RanGTP-RanBP1 complex kcat = 10.8 /sec Km = 0.1 uM at 25oC Table 1. Gorlich D et al (2003) EMBO J 22(5):1088-1100 | | 2 | RanGAP /
RanGAP[1]
| RanGTPase
Accession No. : 70 | Cytoplasm
Pathway No. : 306 | 0.699998 | 10.6 | 4 | explicit E-S complex | Substrate
GTP.Ran-cytoplas
mic
Product
GDP.Ran-cytoplas
mic
| | | RanGAP reaction on free RanGTP kcat = 10.6 /sec Km = 0.7 uM at 25oC Table 1. Gorlich D et al (2003) EMBO J 22(5):1088-1100 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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