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Molecule Parameter List for PLA2-Ca* | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Ajay_Bhalla_
2004_PKM_Tuning | 76 | Network |
PKC, Shared_Object_Ajay_Bhalla_2004_PKM_tuning, PLA2,
PLCbeta, Gq, MAPK,
Ras, EGFR, Sos,
PLC_g, CaMKII, CaM,
PP1, PP2B, PKA,
AC, PKM | | This model is taken from the Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the reference feedforward model from Figure 8a. |
PLA2-Ca* acting as a Molecule in Ajay_Bhalla_2004_PKM_Tuning Network
PLA2-Ca* acting as an Enzyme in Ajay_Bhalla_2004_PKM_Tuning Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PLA2-Ca* /
kenz
| Ajay_Bhalla_
2004_PKM_Tuning
Accession No. : 76 | PLA2
Pathway No. : 314 | 20 | 5.4 | 4 | explicit E-S complex | Substrate
APC
Product
AA
| | 10 x raise oct22 12 x oct 24, set k2 = 4 * k3 |
PLA2-Ca* acting as a Substrate in a reaction in Ajay_Bhalla_2004_PKM_Tuning Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | PIP2-Ca-PLA2-act | Ajay_Bhalla_
2004_PKM_Tuning
Accession No. : 76 | PLA2
Pathway No. : 314 | 0.012
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 8.3335(uM) | - | Substrate
PLA2-Ca*
temp-PIP2
Product
PIP2-Ca-PLA2*
| | 2 | DAG-Ca-PLA2-act | Ajay_Bhalla_
2004_PKM_Tuning
Accession No. : 76 | PLA2
Pathway No. : 314 | 0.003
(uM^-1 s^-1) | 4
(s^-1) | Kd(bf) = 1333.3467(uM) | - | Substrate
DAG
PLA2-Ca*
Product
DAG-Ca-PLA2*
| | | 27 June 1996 Scaled kf down by 0.015 from 3.33e-7 to 5e-9 to fit with revised DAG estimates and use of mole-fraction to calculate eff on PLA2. |
PLA2-Ca* acting as a Product in a reaction in Ajay_Bhalla_2004_PKM_Tuning Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | PLA2-Ca-act | Ajay_Bhalla_
2004_PKM_Tuning
Accession No. : 76 | PLA2
Pathway No. : 314 | 1
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate
Ca
PLA2-cytosolic
Product
PLA2-Ca*
| | Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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