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Molecule Parameter List for PKM-zeta

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

PKM-zeta participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	0	1	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning	77	Network	Shared_Object_Ajay_Bhalla_2004_PKM_MKP3_Tuning,  PKC,  PLA2,   PLCbeta,  Ras,  Gq,   MAPK,  EGFR,  Sos,   PLC_g,  CaMKII,  CaM,   PP1,  PP2B,  PKA,   AC,  MKP3,  PKM
This model is based on Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedforward model with MPK3 from figure 8a.

PKM-zeta acting as a Molecule in  Ajay_Bhalla_2004_PKM_MKP3_Tuning Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PKM-zeta	Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Accession No. : 77	PKC Pathway No. : 330	0.0556	1.5	No

PKM-zeta acting as a Summed Molecule in  Ajay_Bhalla_2004_PKM_MKP3_Tuning Network

Accession Name	Pathway Name	Target	Input
Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Accession No. : 77	Shared_Object_ Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Pathway No. : 329	PKC-active	PKC-Ca-memb* PKC-DAG-memb* PKM-zeta

PKM-zeta acting as a Product of an Enzyme in  Ajay_Bhalla_2004_PKM_MKP3_Tuning Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PKM_synthesis  / kenz	Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Accession No. : 77	PKM Pathway No. : 346	9.99992	0.05	4	explicit E-S complex	Substrate AA_pool Product PKM-zeta

PKM-zeta acting as a Substrate in a reaction in  Ajay_Bhalla_2004_PKM_MKP3_Tuning Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
PKM_degradation	Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Accession No. : 77	PKM Pathway No. : 346	0.0005 (s^-1)	0 (s^-1)	-	-	Substrate PKM-zeta Product degraded_PKM
Time-course of 2 hours.