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Molecule Parameter List for G*GDP | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Ajay_Bhalla_
2004_PKM_MKP3_
Tuning | 77 | Network |
Shared_Object_Ajay_Bhalla_2004_PKM_MKP3_Tuning, PKC, PLA2,
PLCbeta, Ras, Gq,
MAPK, EGFR, Sos,
PLC_g, CaMKII, CaM,
PP1, PP2B, PKA,
AC, MKP3, PKM | | This model is based on Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedforward model with MPK3 from figure 8a. |
G*GDP acting as a Molecule in Ajay_Bhalla_2004_PKM_MKP3_Tuning Network
G*GDP acting as a Substrate in a reaction in Ajay_Bhalla_2004_PKM_MKP3_Tuning Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | Trimerize-G | Ajay_Bhalla_
2004_PKM_MKP3_
Tuning
Accession No. : 77 | Gq
Pathway No. : 334 | 6
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
BetaGamma
G*GDP
Product
G-GDP
| | kf == kg3 = 1e-5 /cell/sec. As usual, there is no back-reaction kb = 0 |
G*GDP acting as a Product in a reaction in Ajay_Bhalla_2004_PKM_MKP3_Tuning Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | Inact-PLC-Gq | Ajay_Bhalla_
2004_PKM_MKP3_
Tuning
Accession No. : 77 | PLCbeta
Pathway No. : 332 | 0.0133
(s^-1) | 0
(uM^-1 s^-1) | - | - | Substrate
PLC-Ca-Gq
Product
G*GDP
PLC-Ca
| | | This process is assumed to be directly caused by the inactivation of the G*GTP to G*GDP. Hence, kf = .013 /sec = 0.8/min, same as the rate for Inact-G. kb = 0 since this is irreversible. We may be interested in studying the role of PLC as a GAP. If so, the kf would be faster here than in Inact-G | | 2 | Inact-G | Ajay_Bhalla_
2004_PKM_MKP3_
Tuning
Accession No. : 77 | Gq
Pathway No. : 334 | 0.0133
(s^-1) | 0
(s^-1) | - | - | Substrate
G*GTP
Product
G*GDP
| | | From Berstein et al JBC 267:12 8081-8088 1992, kcat for GTPase activity of Gq is only 0.8/min |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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