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Molecule Parameter List for PP2A

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PP2A participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1020000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2004_PKM_MKP3_
    Tuning
    		• 77Network
    Shared_Object_Ajay_Bhalla_2004_PKM_MKP3_Tuning,  PKC,  PLA2,  
    PLCbeta,  Ras,  Gq,  
    MAPK,  EGFR,  Sos,  
    PLC_g,  CaMKII,  CaM,  
    PP1,  PP2B,  PKA,  
    AC,  MKP3,  PKM 
    This model is based on Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedforward model with MPK3 from figure 8a.

    PP2A acting as a Molecule in      Ajay_Bhalla_2004_PKM_MKP3_Tuning Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    PP2A
  • Ajay_Bhalla_
    2004_PKM_MKP3_
    Tuning
    Accession No. : 77
  • Shared_Object_
    Ajay_Bhalla_
    2004_PKM_MKP3_
    Tuning
    Pathway No. : 329
    		• 0.121.5No

    PP2A acting as an Enzyme in      Ajay_Bhalla_2004_PKM_MKP3_Tuning Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PP2A /
  • PP2A-dephosph-I1
  • Ajay_Bhalla_
    2004_PKM_MKP3_
    Tuning
    Accession No. : 77
  • Shared_Object_
    Ajay_Bhalla_
    2004_PKM_MKP3_
    Tuning
    Pathway No. : 329
    		• 7.8282864.16667explicit E-S complexSubstrate
    I1*

    Product
    I1
        PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
    2PP2A /
  • PP2A-dephosph-PP
    1-I*
  • Ajay_Bhalla_
    2004_PKM_MKP3_
    Tuning
    Accession No. : 77
  • Shared_Object_
    Ajay_Bhalla_
    2004_PKM_MKP3_
    Tuning
    Pathway No. : 329
    		• 7.8282864.16667explicit E-S complexSubstrate
    PP1-I1*

    Product
    PP1-I1
        k1 changed from 3.3e-6 to 6.6e-6


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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