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Molecule Parameter List for MKP3_synthesis

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*MKP3_synthesis* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	0	1	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning	77	Network	Shared_Object_Ajay_Bhalla_2004_PKM_MKP3_Tuning, PKC, PLA2, PLCbeta, Ras, Gq, MAPK, EGFR, Sos, PLC_g, CaMKII, CaM, PP1, PP2B, PKA, AC, MKP3, PKM
This model is based on Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedforward model with MPK3 from figure 8a.

MKP3_synthesis acting as a Molecule in Ajay_Bhalla_2004_PKM_MKP3_Tuning Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
MKP3_synthesis	Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Accession No. : 77	MKP3 Pathway No. : 345	0.0014	1.5	No

MKP3_synthesis acting as an Enzyme in Ajay_Bhalla_2004_PKM_MKP3_Tuning Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
MKP3_synthesis / kenz	Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Accession No. : 77	MKP3 Pathway No. : 345	0.199998	0.01	4	explicit E-S complex	Substrate MKP3_AA Product MKP-3

MKP3_synthesis acting as a Product of an Enzyme in Ajay_Bhalla_2004_PKM_MKP3_Tuning Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
nuc_MAPK* / act_ transcription	Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Accession No. : 77	MKP3 Pathway No. : 345	3.99997	0.004	4	explicit E-S complex	Substrate nucleotides Product MKP3_synthesis

MKP3_synthesis acting as a Product in a reaction in Ajay_Bhalla_2004_PKM_MKP3_Tuning Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
basal_ transcription	Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Accession No. : 77	MKP3 Pathway No. : 345	0 (s^-1)	0.001 (s^-1)	Keq = 1000(uM)	-	Substrate nucleotides Product MKP3_synthesis
Reverse reaction is for turning off the synthesis.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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