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Molecule Parameter List for tot_CaM_CaMKII

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

tot_CaM_CaMKII participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	2	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning	77	Network	Shared_Object_Ajay_Bhalla_2004_PKM_MKP3_Tuning,  PKC,  PLA2,   PLCbeta,  Ras,  Gq,   MAPK,  EGFR,  Sos,   PLC_g,  CaMKII,  CaM,   PP1,  PP2B,  PKA,   AC,  MKP3,  PKM
This model is based on Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedforward model with MPK3 from figure 8a.

tot_CaM_CaMKII acting as a Molecule in  Ajay_Bhalla_2004_PKM_MKP3_Tuning Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
tot_CaM_CaMKII	Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Accession No. : 77	CaMKII Pathway No. : 339	0	1.5	No

tot_CaM_CaMKII acting as a Summed Molecule in  Ajay_Bhalla_2004_PKM_MKP3_Tuning Network

Accession Name	Pathway Name	Target	Input
Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Accession No. : 77	CaMKII Pathway No. : 339	tot_CaM_CaMKII	CaMKII-CaM CaMKII-thr286*-C aM

tot_CaM_CaMKII acting as an Enzyme in  Ajay_Bhalla_2004_PKM_MKP3_Tuning Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot_CaM_CaMKII / CaM_act_305	Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Accession No. : 77	CaMKII Pathway No. : 339	113.599	6	4	explicit E-S complex	Substrate CaMKII-thr286 Product CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
2	tot_CaM_CaMKII / CaM_act_286	Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Accession No. : 77	CaMKII Pathway No. : 339	113.601	0.5	4	explicit E-S complex	Substrate CaMKII-CaM Product CaMKII-thr286*-C aM