 |  Ajay_Bhalla_
2007_ReacDiff1_
1e-13 |
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Accession information for Ajay_Bhalla_2007_ReacDiff1_1e-13 (Accession Number 82)
Reaction Scheme
Accession Basic Parameters
| Name | Ajay_Bhalla_2007_ReacDiff1_1e-13 |
| Accession Type | Network |
| Transcriber | Upinder S. Bhalla, NCBS |
| Developer | Upinder S. Bhalla, NCBS |
| Entry Date (YYYY-MM-DD) | 2006-12-08 00:00:00 |
| Species | Rat |
| Tissue | Hippocampal CA1 |
| Cell Compartment | Dendrite |
| Source | Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87 |
| Methodology | Semi-Quantitative match to experiments |
| Model Implementation | Exact GENESIS implementation |
| Model Validation | Replicates original data |
| Notes | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec.
The stimulus file pkm_mapk22_diff_1e-13_Fig4B which was used for the model to replicate Figure 4B from the paper.
pkm_mapk22_diff_1e-13_Fig4H replicate Figure 4H.
pkm_mapk22_diff_1e-13_Fig4I replicate Figure 4I.
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| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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