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Molecule Parameter List for PIP3_AKT-t308_s473

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

PIP3_AKT-t308_s473 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	1	1	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AKT	87	Network	Shared_Object_AKT,  AKT_mod
This is one of the sub-model of BDNF signaling cascade. PIP3 activies AKT, leading to accumulation of Rheb-GTP, a regulator of mTOR.

PIP3_AKT-t308_s473 acting as a Molecule in  AKT Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PIP3_AKT-t308_s473	AKT Accession No. : 87	AKT_mod Pathway No. : 1086	0	999.97	No
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PIP3_AKT-t308_s473 acting as an Enzyme in  AKT Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PIP3_AKT-t308_ s473 / TSC2_phospho	AKT Accession No. : 87	AKT_mod Pathway No. : 1086	10.2999	6	4	explicit E-S complex	Substrate TSC1-TSC2 Product TSC1-TSC2*

PIP3_AKT-t308_s473 acting as a Substrate for an Enzyme in  AKT Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PP2A  / Dephos_ AKTser473	AKT Accession No. : 87	Shared_Object_ AKT Pathway No. : 1085	4.8	1.8	4	explicit E-S complex	Substrate PIP3_AKT-t308_ s473 Product PIP3_AKT_thr308

PIP3_AKT-t308_s473 acting as a Product of an Enzyme in  AKT Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PIP3_PDK2  / phosp_AKTser473	AKT Accession No. : 87	AKT_mod Pathway No. : 1086	0.800013	20	4	explicit E-S complex	Substrate PIP3_AKT_thr308 Product PIP3_AKT-t308_ s473