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Molecule Parameter List for 4E-BP | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | 4EBP | 89 | Network |
Shared_Object_4EBP, mTOR_model, 4E-BP_mod | | Rheb-GTP activates mTOR, again with regulation by MAPK, leading to formation of the eIF4F-mRNA complex. |
4E-BP acting as a Molecule in 4EBP Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | 4E-BP | 4EBP
Accession No. : 89 | 4E-BP_mod
Pathway No. : 1092 | 0 | 1000 | No |
4E-BP acting as a Substrate for an Enzyme in 4EBP Network
4E-BP acting as a Product of an Enzyme in 4EBP Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PP2A /
PP2A_4E-BP* | 4EBP
Accession No. : 89 | Shared_Object_
4EBP
Pathway No. : 1090 | 8.8 | 1 | 4 | explicit E-S complex | Substrate
4E-BP_t37_46
Product
4E-BP
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4E-BP acting as a Substrate in a reaction in 4EBP Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | eIF4E_bind_BP2 | 4EBP
Accession No. : 89 | 4E-BP_mod
Pathway No. : 1092 | 49.999
(uM^-1 s^-1) | 0.15
(s^-1) | Kd(bf) = 0.003(uM) | - | Substrate
4E-BP
eIF4E
Product
eIF4E-BP
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| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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