DOQCS database

NCBS Home page

Accession List

Pathway List

Authorized Users

Help

News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.

Molecule Parameter List for 4E-BP_t37_46

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*4E-BP_t37_46* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	2	2	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
4EBP	89	Network	Shared_Object_4EBP, mTOR_model, 4E-BP_mod
Rheb-GTP activates mTOR, again with regulation by MAPK, leading to formation of the eIF4F-mRNA complex.

4E-BP_t37_46 acting as a Molecule in 4EBP Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
4E-BP_t37_46	4EBP Accession No. : 89	Shared_Object_ 4EBP Pathway No. : 1090	0	1000	No

4E-BP_t37_46 acting as a Summed Molecule in 4EBP Network

Accession Name	Pathway Name	Target	Input
4EBP Accession No. : 89	Shared_Object_ 4EBP Pathway No. : 1090	4E-BP_tot	eIF4E-BP_thr37_ 46 eIF4E_4E-BP_ t37_46_s65 4E-BP_thr37_46_ s65 4E-BP_t37_46

4E-BP_t37_46 acting as a Substrate for an Enzyme in 4EBP Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP2A / PP2A_4E-BP*	4EBP Accession No. : 89	Shared_Object_ 4EBP Pathway No. : 1090	8.8	1	4	explicit E-S complex	Substrate 4E-BP_t37_46 Product 4E-BP
2	MAPK* / MAPK_4E-BP**	4EBP Accession No. : 89	Shared_Object_ 4EBP Pathway No. : 1090	17.9	0.16	4	explicit E-S complex	Substrate 4E-BP_t37_46 Product 4E-BP_thr37_46_ s65

4E-BP_t37_46 acting as a Product of an Enzyme in 4EBP Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP2A / PP2A_4E-BP**	4EBP Accession No. : 89	Shared_Object_ 4EBP Pathway No. : 1090	8.8	1	4	explicit E-S complex	Substrate 4E-BP_thr37_46_ s65 Product 4E-BP_t37_46
2	TOR_Rheb-GTP_ clx / TOR_4E-BP*	4EBP Accession No. : 89	Shared_Object_ 4EBP Pathway No. : 1090	1.80001	1	4	explicit E-S complex	Substrate 4E-BP Product 4E-BP_t37_46

4E-BP_t37_46 acting as a Product in a reaction in 4EBP Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
eIF4E-BP_disso	4EBP Accession No. : 89	Shared_Object_ 4EBP Pathway No. : 1090	1 (s^-1)	0.1 (uM^-1 s^-1)	Kd(cb) = 0.1(uM)	-	Substrate eIF4E-BP_thr37_ 46 Product 4E-BP_t37_46 eIF4E

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.