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Molecule Parameter List for MKP-1-ser359* | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
MKP-1-ser359* acting as a Molecule in MAPK_MKP1_oscillation Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | MKP-1-ser359* | MAPK_MKP1_
oscillation
Accession No. : 9 | MAPK
Pathway No. : 61 | 0 | 1000 | No | | |
MKP-1-ser359* acting as a Substrate for an Enzyme in MAPK_MKP1_oscillation Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | MAPK* /
MKP-1-phosph2 | MAPK_MKP1_
oscillation
Accession No. : 9 | Shared_Object_
MAPK_MKP1_
oscillation
Pathway No. : 59 | 25.641 | 1 | 4 | explicit E-S complex | Substrate
MKP-1-ser359*
Product
MKP-1**
| | 3 Feb 2000. See Brondello et al Science 286:2514 1999. Rates assumed standard MAPK rates based on Sanghera et al JBC 265(1):53-57 1990. 24 Apr 2K, based on 12 Feb 2K: Scaled x0.1 to 3.25e-7,4,1 |
MKP-1-ser359* acting as a Product of an Enzyme in MAPK_MKP1_oscillation Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | MAPK* /
MKP-1-phosph | MAPK_MKP1_
oscillation
Accession No. : 9 | Shared_Object_
MAPK_MKP1_
oscillation
Pathway No. : 59 | 25.641 | 1 | 4 | explicit E-S complex | Substrate
MKP-1
Product
MKP-1-ser359*
| | 3 Feb 2000. See Brondello et al Science 286:2514 1999. Rates assumed standard MAPK rates based on Sanghera et al JBC 265(1):53-57 1990. 24 Apr 2K, based on 12 Feb 2K: scaled by 0.1 to 3.25e-7,4,1 |
MKP-1-ser359* acting as a Substrate in a reaction in MAPK_MKP1_oscillation Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | turnover_MKP1* | MAPK_MKP1_
oscillation
Accession No. : 9 | MAPK
Pathway No. : 61 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
MKP-1-ser359*
Product
Ubiquitination
| | | 3 Feb 2000. Rate of turnover of phosph form of MKP1 is from Brondello et al Science 286:2514 1999. Tau is about 150 min though it is not a clean exp falloff. | | 2 | MKP-1*dephosph | MAPK_MKP1_
oscillation
Accession No. : 9 | MAPK
Pathway No. : 61 | 0.01
(s^-1) | 0
(s^-1) | - | - | Substrate
MKP-1-ser359*
Product
MKP-1
| | | 24 Apr 2K: Based on 12 Feb 2K: Scaled up 10x so kf=0.01, kb=0 |
MKP-1-ser359* acting as a Product in a reaction in MAPK_MKP1_oscillation Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | MKP-1**dephosph | MAPK_MKP1_
oscillation
Accession No. : 9 | MAPK
Pathway No. : 61 | 0.01
(s^-1) | 0
(s^-1) | - | - | Substrate
MKP-1**
Product
MKP-1-ser359*
| | 24 Apr 2K, based on 12 Feb 2K: Scaled up 10x to kf=0.01, kb=0 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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