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Name Notes Model

Molecule Parameter List for Ubiquitination

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

Ubiquitination participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	0	3

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
MAPK_MKP1_ oscillation	9	Network	Shared_Object_MAPK_MKP1_oscillation,  PKC,  MAPK,   PLA2,  Ras
This model relates to figure 5 in Bhalla US, Iyengar R. Chaos (2001) 11(1):221-226. It includes the model used for figures 2-4 and also has MKP-1 induction by MAPK activity in the synapse. PP2A is set to 0.16 uM and MKP synthesis is varied from 5x to 40 x basal to get a range of interesting behaviours.

Ubiquitination acting as a Molecule in  MAPK_MKP1_oscillation Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Ubiquitination	MAPK_MKP1_ oscillation Accession No. : 9	MAPK Pathway No. : 61	0	1000	Yes

Ubiquitination acting as a Product in a reaction in  MAPK_MKP1_oscillation Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	turnover_MKP1	MAPK_MKP1_ oscillation Accession No. : 9	MAPK Pathway No. : 61	0.0004 (s^-1)	0 (s^-1)	-	-	Substrate MKP-1 Product Ubiquitination
	3 Feb 2000. Rate of turnover of non-phosph form of MKP1 is from Brondello et al Science 286:2514 1999. Tau is about 45 min.
2	turnover_MKP1**	MAPK_MKP1_ oscillation Accession No. : 9	MAPK Pathway No. : 61	0.0001 (s^-1)	0 (s^-1)	-	-	Substrate MKP-1** Product Ubiquitination
	3 Feb 2000. Rate of turnover of phosph form of MKP1 is from Brondello et al Science 286:2514 1999. Tau is about 150 min though it is not a clean exp falloff.
3	turnover_MKP1*	MAPK_MKP1_ oscillation Accession No. : 9	MAPK Pathway No. : 61	0.0001 (s^-1)	0 (s^-1)	-	-	Substrate MKP-1-ser359* Product Ubiquitination
	3 Feb 2000. Rate of turnover of phosph form of MKP1 is from Brondello et al Science 286:2514 1999. Tau is about 150 min though it is not a clean exp falloff.