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Molecule Parameter List for temp-PIP2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
temp-PIP2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000020

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK_MKP1_
    oscillation
    		• 9Network
    Shared_Object_MAPK_MKP1_oscillation,  PKC,  MAPK,  
    PLA2,  Ras 
    This model relates to figure 5 in Bhalla US, Iyengar R. Chaos (2001) 11(1):221-226. It includes the model used for figures 2-4 and also has MKP-1 induction by MAPK activity in the synapse. PP2A is set to 0.16 uM and MKP synthesis is varied from 5x to 40 x basal to get a range of interesting behaviours.

    temp-PIP2 acting as a Molecule in      MAPK_MKP1_oscillation Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    temp-PIP2
  • MAPK_MKP1_
    oscillation
    Accession No. : 9
  • Shared_Object_
    MAPK_MKP1_
    oscillation
    Pathway No. : 59
    		• 2.51000Yes
    This isn't explicitly present in the M&L model, but is obviously needed. I assume its conc is fixed at 1uM for now, which is a bit high. PLA2 is stim 7x by PIP2 @ 0.5 uM (Leslie and Channon BBA 1045:261(1990) Leslie and Channon say PIP2 is present at 0.1 - 0.2mol% range in membs, which comes to 50 nM. Ref is Majerus et al Cell 37 pp 701-703 1984 Lets use a lower level of 30 nM, same ref....

    temp-PIP2 acting as a Substrate in a reaction in      MAPK_MKP1_oscillation Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1PIP2-PLA2-act
  • MAPK_MKP1_
    oscillation
    Accession No. : 9
    		• PLA2
    Pathway No. : 62    		0.0012
    (uM^-1 s^-1)    		0.5
    (s^-1)    		Kd(bf) = 416.6667(uM)-Substrate
    PLA2-cytosolic
    temp-PIP2

    Product
    PIP2-PLA2*
    2
  • PIP2-Ca-PLA2-act
  • MAPK_MKP1_
    oscillation
    Accession No. : 9
    		• PLA2
    Pathway No. : 62    		0.012
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 8.3333(uM)-Substrate
    PLA2-Ca*
    temp-PIP2

    Product
    PIP2-Ca-PLA2*


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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