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Molecule Parameter List for CaMKIII

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

CaMKIII participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	2	0	1	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CaMKIII	90	Network	Shared_Object_CaMKIII,  CaM
CaMKIII is activated by Ca2+ and inactivated by S6K. Since CaMKIII inhibits eEF2, the net effect of Ca2+ on elongation is inhibitory and of S6K is excitatory

CaMKIII acting as a Molecule in  CaMKIII Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMKIII	CaMKIII Accession No. : 90	Shared_Object_ CaMKIII Pathway No. : 1093	0.06	1000	No

CaMKIII acting as a Substrate for an Enzyme in  CaMKIII Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	S6K_thr-252  / camkIII_phospho	CaMKIII Accession No. : 90	Shared_Object_ CaMKIII Pathway No. : 1093	1	1	4	explicit E-S complex	Substrate CaMKIII Product CaMKIII*
2	S6K_basal  / CaMKIII_basal	CaMKIII Accession No. : 90	Shared_Object_ CaMKIII Pathway No. : 1093	0.999896	10	4	explicit E-S complex	Substrate CaMKIII Product CaMKIII*

CaMKIII acting as a Substrate in a reaction in  CaMKIII Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
CaMKIII_bind_ CaM-Ca4	CaMKIII Accession No. : 90	Shared_Object_ CaMKIII Pathway No. : 1093	99 (uM^-1 s^-1)	0.09 (s^-1)	Kd(bf) = 0.0009(uM)	-	Substrate CaM-Ca4 CaMKIII Product CaMKIII_CaM-Ca4

CaMKIII acting as a Product in a reaction in  CaMKIII Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
dephosp_CaMKIII	CaMKIII Accession No. : 90	Shared_Object_ CaMKIII Pathway No. : 1093	0.07 (s^-1)	0 (s^-1)	-	-	Substrate CaMKIII* Product CaMKIII