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Molecule Parameter List for CaM-Ca4

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaM-Ca4 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
CaMKIII90Network
Shared_Object_CaMKIII,  CaM 
CaMKIII is activated by Ca2+ and inactivated by S6K. Since CaMKIII inhibits eEF2, the net effect of Ca2+ on elongation is inhibitory and of S6K is excitatory

CaM-Ca4 acting as a Molecule in  CaMKIII Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
CaM-Ca4CaMKIII
Accession No. : 90
  • Shared_Object_
    CaMKIII
    Pathway No. : 1093
    		• 01000No

    CaM-Ca4 acting as a Substrate in a reaction in      CaMKIII Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • CaMKIII_bind_
    CaM-Ca4
    		• CaMKIII
    Accession No. : 90
  • Shared_Object_
    CaMKIII
    Pathway No. : 1093
    		• 99
    (uM^-1 s^-1)    		0.09
    (s^-1)    		Kd(bf) = 0.0009(uM)-Substrate
    CaM-Ca4
    CaMKIII

    Product
    CaMKIII_CaM-Ca4

    CaM-Ca4 acting as a Product in a reaction in      CaMKIII Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    CaM-Ca3-bind-CaCaMKIII
    Accession No. : 90    		CaM
    Pathway No. : 1094    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5051(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4
    Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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