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Molecule List for pathway PKA (Pathway Number 84) in Accession Synaptic_Network (Accession Number 16) |
Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.  arrow indicates that ordering is done according to ascending or descending order.The entries are grouped according to Pathway Number and are alternately color coded using  and  color. |
| Name | Accession Type | Initial Conc. (uM) | Volume (fL) | Buffered | Sum Total Of | |||
| 1 | R2C2 | Network | 0.5 | 1000 | No | - | ||
| This is the R2C2 complex, consisting of 2 catalytic (C) subunits, and the R-dimer. See Taylor et al Ann Rev Biochem 1990 59:971-1005 for a review. The Doskeland and Ogreid review is better for numbers. Amount of PKA is about .5 uM. | ||||||||
| 2 | R2C2-cAMP | Network | 0 | 1000 | No | - | ||
| One cAMP bound to site B1 on the regulatory subunits. | ||||||||
| 3 | R2C2-cAMP2 | Network | 0 | 1000 | No | - | ||
| One cAMP bound to each of the B sites on the regulatory subunits. | ||||||||
| 4 | R2C2-cAMP3 | Network | 0 | 1000 | No | - | ||
| 3 cAMPs now bound. | ||||||||
| 5 | R2C2-cAMP4 | Network | 0 | 1000 | No | - | ||
| All the regulatory subunits now have cAMP bound. This state is ready to dissociate and to release the catalytic subunit. | ||||||||
| 6 | R2C-cAMP4 | Network | 0 | 1000 | No | - | ||
| 7 | R2-cAMP4 | Network | 0 | 1000 | No | - | ||
| The regulatory subunit with 4 cAMPs but the catalytic subunit has been released. | ||||||||
| 8 | PKA-inhibitor | Network | 0.25 | 1000 | No | - | ||
| About 25% of PKA C subunit is dissociated in resting cells without having any noticable activity. Doskeland and Ogreid Int J biochem 13 pp1-19 suggest that this is because there is a corresponding amount of inhibitor protein. | ||||||||
| 9 | inhibited-PKA | Network | 0 | 1000 | No | - | ||
| This is the inhibitor bound to PKA. | ||||||||