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Parameters for PKA (Pathway Number 84) Pathway Layout
Pathway Basic Parameters Pathway Name | PKA | Pathway Entry Number | 84 | Accession Number | 16 | Accession Name | Synaptic_Network | Species | Generic mammalian | Tissue | Neuronal | CellCompartment | Synapse | Related Pathways | 17,
30,
135,
196,
220,
240,
250,
270,
277,
288,
326,
343,
361
| Notes | Protein kinase A. It has two regulatory and two catalytic subunits, represented here as R2C2. Each regulatory subunit binds two cAMPs. I also model an inhibitor of PKA which binds stoichiometrically and thus sharpens the response curve for PKA against cAMP. General reference: Taylor et al Ann Rev Biochem 1990 59:971-1005 Other references Ogreid and Doskeland 1983 Biochem 22:1686-1696 is a great, detailed paper. Also: Ogreid and Doskeland 1982 FEBS Lett 150(1):161-166 Ogreid et al 1983 JBC 258(2):1041-1049 Robinson-Steiner and Corbin 1983 JBC 258(2):1032-1040 Hasler et al 1992 FASEB J 6:2735-2741
| Statistics Conversion formatThis pathway is part of accession 16 and is completely specified in the file acc16.g. There is no separate files for just this pathway. |
Format | File | Native Format (GENESIS format) | acc16.g | GENESIS Format (Annotated version) | Anno_acc16.g |
Pathway Detail Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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