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Accession Type:
Network
Synaptic_
Network
Shared_Object_
Synaptic_
Network
PKC
PLA2
PLCbeta
Gq
MAPK
Ras
EGFR
Sos
PLC_g
CaMKII
CaM
PP1
PP2B
PKA
 Molecule
 Reaction
AC
CaRegulation

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Parameters for PKA (Pathway Number 84)

Pathway Layout

Pathway Basic Parameters

Pathway NamePKA
Pathway Entry Number 84
Accession Number 16
Accession Name Synaptic_Network
Species Generic mammalian
Tissue Neuronal
CellCompartmentSynapse
Related Pathways 17, 30, 135, 196, 220, 240, 250, 270, 277, 288, 326, 343, 361
Notes Protein kinase A. It has two regulatory and two catalytic subunits, represented here as R2C2. Each regulatory subunit binds two cAMPs. I also model an inhibitor of PKA which binds stoichiometrically and thus sharpens the response curve for PKA against cAMP. General reference: Taylor et al Ann Rev Biochem 1990 59:971-1005 Other references Ogreid and Doskeland 1983 Biochem 22:1686-1696 is a great, detailed paper. Also: Ogreid and Doskeland 1982 FEBS Lett 150(1):161-166 Ogreid et al 1983 JBC 258(2):1041-1049 Robinson-Steiner and Corbin 1983 JBC 258(2):1032-1040 Hasler et al 1992 FASEB J 6:2735-2741

Statistics

Enzyme sites
9
0
7

Conversion format

This pathway is part of accession 16 and is completely specified in the file acc16.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc16.g   
GENESIS Format (Annotated version)    Anno_acc16.g   


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Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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