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Accession Type:
Network
Synaptic_
Network
Shared_Object_
Synaptic_
Network
PKC
PLA2
PLCbeta
Gq
MAPK
Ras
EGFR
Sos
PLC_g
CaMKII
CaM
PP1
PP2B
PKA
AC
CaRegulation
 Molecule
 Enzyme
 Reaction

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Parameters for CaRegulation (Pathway Number 86)

Pathway Layout

Pathway Basic Parameters

Pathway NameCaRegulation
Pathway Entry Number 86
Accession Number 16
Accession Name Synaptic_Network
Species Generic mammalian
Tissue Neuronal
CellCompartmentSynapse
Related Pathways 11, 110, 132, 149, 170
Notes This simple implementation of Ca regulation includes three compartments: the extracellular, the intracellular, and the Ca stores. Pumps maintain the Ca levels in cytoplasm (pumping out to the extracellular space and into the stores). Leak channels from the stores and extracellular space balance it out. Finally, the IP3 receptor and the capacitive entry channel respond to stimuli of various kinds. One clear direction for further work is to incorporate various calcium buffering proteins such as calsequestrin into the model. Primary reference is from the book Receptors: Models for binding, trafficking and signaling, by Lauffenburger and Linderman, OUP, 1993, Ch 5, around pg 200. There is extensive reference to a submitted paper by Mahama and Linderman, whose published version appears to be Mahama and Linderman 1994 Biophys J 67(3):1345-1357 This model is a little artificial on the IP3R kinetics and does not include the Ca influence on IP3R.

Statistics

11
1
4

Conversion format

This pathway is part of accession 16 and is completely specified in the file acc16.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc16.g   
GENESIS Format (Annotated version)    Anno_acc16.g   


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Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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